The effects of conjugated linoleic acid supplementation on blood pressure and endothelial function in adults: A systematic review and dose-response meta-analysis

Omid Asbaghi; Ghazaleh Shimi; Kaveh Naseri; Saeede Saadati; Mahnaz Rezaei Kelishadi; Saeid Doaei; Neda Haghighat

doi:10.1016/j.ejphar.2022.175162

The effects of conjugated linoleic acid supplementation on blood pressure and endothelial function in adults: A systematic review and dose-response meta-analysis

Eur J Pharmacol. 2022 Sep 15:931:175162. doi: 10.1016/j.ejphar.2022.175162. Epub 2022 Aug 5.

Authors

Omid Asbaghi¹, Ghazaleh Shimi², Kaveh Naseri³, Saeede Saadati⁴, Mahnaz Rezaei Kelishadi⁵, Saeid Doaei⁶, Neda Haghighat⁷

Affiliations

¹ Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: omid.asbaghi@gmail.com.
² Department of Cellular and Molecular Nutrition, Faculty of Nutrition Science and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, 1981619573, Tehran, Iran. Electronic address: ghazaleh_shimi@yahoo.com.
³ Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: naserikaveh1@gmail.com.
⁴ Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia. Electronic address: saadatisaeede@gmail.com.
⁵ Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: m.rezaei81@yahoo.com.
⁶ Reproductive Health Research Center, Department of Obstetrics & Gynecology, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: Sdoaei@sbmu.ac.ir.
⁷ Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: neda.hag@gmail.com.

PMID: 35940238
DOI: 10.1016/j.ejphar.2022.175162

Abstract

Background: Findings of studies investigating the effect of conjugated linoleic acid (CLA) supplementation on blood pressure (BP) and endothelial function are controversial.

Method: This meta-analysis of randomized controlled trials (RCTs) was performed to explore the effects of CLA supplementation on BP and endothelial function. Two authors independently searched electronic databases using PubMed, Web of Science, and Scopus until March 2022, in order to find relevant RCTs.

Results: Eighteen RCTs with 20 effect sizes met the inclusion criteria and were eligible for meta-analysis. CLA supplementation did not significantly alter systolic blood pressure (SBP) (WMD: -0.48; 95% CI: -3.23, 2.27), diastolic blood pressure (DBP) (WMD: -0.71; 95% CI: -3.54, 2.12), and vascular cell adhesion molecule (VCAM) (WMD: -34.02; 95% CI: -88.08, 20.03) levels. However, CLA supplementation significantly reduced intercellular adhesion molecule (ICAM) (WMD: -8.02; 95% CI: -13.95, -2.09) level.

Conclusion: This systematic review and meta-analysis showed CLA association with reduction of ICAM. The PROSPERO registration number: CRD42022331108.

Keywords: Blood pressure; Conjugated linoleic acid; Endothelial function; Systematic review; meta-Analysis.

Publication types

Meta-Analysis
Review
Systematic Review

MeSH terms

Blood Pressure
Dietary Supplements
Endothelium
Linoleic Acids, Conjugated* / pharmacology
Vascular Cell Adhesion Molecule-1

Substances

Linoleic Acids, Conjugated
Vascular Cell Adhesion Molecule-1