Abstract
We evaluated antibiotic resistance selection in Streptococcus pneumoniae isolates from children participating in an individually randomized trial of single-dose azithromycin versus placebo. After 14 days, the prevalence of resistance to erythromycin, oxacillin, and clindamycin was elevated in the azithromycin versus placebo group. There was no difference at 6 months.
Trial registration:
ClinicalTrials.gov NCT03676751.
Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use
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Azithromycin* / pharmacology
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Azithromycin* / therapeutic use
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Carrier State / drug therapy
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Carrier State / epidemiology
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Child
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Clindamycin / pharmacology
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Clindamycin / therapeutic use
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Drug Resistance, Bacterial
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Humans
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Infant
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Microbial Sensitivity Tests
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Nasopharynx
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Pneumococcal Infections* / drug therapy
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Pneumococcal Infections* / epidemiology
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Streptococcus pneumoniae
Substances
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Anti-Bacterial Agents
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Clindamycin
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Azithromycin
Associated data
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ClinicalTrials.gov/NCT03676751