OPA1 regulation of mitochondrial dynamics in skeletal and cardiac muscle

Trends Endocrinol Metab. 2022 Oct;33(10):710-721. doi: 10.1016/j.tem.2022.07.003. Epub 2022 Aug 6.


The mitochondria are double-membrane organelles integral for energy metabolism. Mitochondrial dynamics is regulated by inner and outer mitochondrial membrane (IMM and OMM) proteins, which promote fission and fusion. Optic atrophy 1 (OPA1) regulates IMM fusion, prevents apoptosis, and is a key regulator of morphological change in skeletal and cardiac muscle physiology and pathophysiology. OPA1 fuses the inner membranes of adjacent mitochondria, allowing for an increase in oxidative phosphorylation (OXPHOS). Considering the importance of energy metabolism in whole-body physiology, OPA1 and its regulators have been proposed as novel targets for the treatment of skeletal muscle atrophy and heart failure. Here, we review the role and regulation of OPA1 in skeletal muscle and cardiac pathophysiology, epitomizing its critical role in the cell.

Keywords: exercise; heart; metabolism; mitochondria; skeletal muscle.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • GTP Phosphohydrolases* / genetics
  • GTP Phosphohydrolases* / metabolism
  • Humans
  • Mitochondria / metabolism
  • Mitochondrial Dynamics*
  • Mitochondrial Membranes / metabolism
  • Mitochondrial Proteins / metabolism
  • Muscle, Skeletal* / metabolism
  • Myocardium* / metabolism


  • Mitochondrial Proteins
  • GTP Phosphohydrolases
  • OPA1 protein, human