Connecting omics signatures and revealing biological mechanisms with iLINCS

Nat Commun. 2022 Aug 9;13(1):4678. doi: 10.1038/s41467-022-32205-3.


There are only a few platforms that integrate multiple omics data types, bioinformatics tools, and interfaces for integrative analyses and visualization that do not require programming skills. Here we present iLINCS ( ), an integrative web-based platform for analysis of omics data and signatures of cellular perturbations. The platform facilitates mining and re-analysis of the large collection of omics datasets (>34,000), pre-computed signatures (>200,000), and their connections, as well as the analysis of user-submitted omics signatures of diseases and cellular perturbations. iLINCS analysis workflows integrate vast omics data resources and a range of analytics and interactive visualization tools into a comprehensive platform for analysis of omics signatures. iLINCS user-friendly interfaces enable execution of sophisticated analyses of omics signatures, mechanism of action analysis, and signature-driven drug repositioning. We illustrate the utility of iLINCS with three use cases involving analysis of cancer proteogenomic signatures, COVID 19 transcriptomic signatures and mTOR signaling.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • COVID-19* / genetics
  • Computational Biology
  • Humans
  • Neoplasms* / genetics
  • Software
  • Transcriptome
  • Workflow