Come on mtDNA, light my fire

Immunity. 2022 Aug 9;55(8):1331-1333. doi: 10.1016/j.immuni.2022.07.011.


Oxidized mitochondrial DNA (ox-mtDNA) activates NLRP3 inflammasome signaling through an ill-defined mechanism. In this issue of Immunity, Xian et al. reveal FEN1 endonuclease cleaves ox-mtDNA into fragments that escape mitochondria, igniting NLRP3 and cGAS-STING signaling and inflammation.

Publication types

  • Comment

MeSH terms

  • DNA, Mitochondrial* / genetics
  • Inflammasomes
  • Mitochondria / genetics
  • NLR Family, Pyrin Domain-Containing 3 Protein*
  • Signal Transduction


  • DNA, Mitochondrial
  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein