Association between Epstein-Barr-Virus reactivation and development of Long-COVID fatigue

doi:10.1111/all.15471

. 2023 Jan;78(1):297-299.

doi: 10.1111/all.15471. Epub 2022 Aug 23.

Association between Epstein-Barr-Virus reactivation and development of Long-COVID fatigue

Affiliations

¹ Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
² Center for Virology, Medical University of Vienna, Vienna, Austria.
³ Division of Macromolecular Chemistry, Institute of Applied Synthetic Chemistry, Vienna University of Technology, Vienna, Austria.
⁴ Facharzt Zentrum Votivpark, Vienna, Austria.

PMID: 35950630
PMCID: PMC9538037
DOI: 10.1111/all.15471

Association between Epstein-Barr-Virus reactivation and development of Long-COVID fatigue

Johanna Rohrhofer et al. Allergy. 2023 Jan.

. 2023 Jan;78(1):297-299.

doi: 10.1111/all.15471. Epub 2022 Aug 23.

Affiliations

¹ Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
² Center for Virology, Medical University of Vienna, Vienna, Austria.
³ Division of Macromolecular Chemistry, Institute of Applied Synthetic Chemistry, Vienna University of Technology, Vienna, Austria.
⁴ Facharzt Zentrum Votivpark, Vienna, Austria.

PMID: 35950630
PMCID: PMC9538037
DOI: 10.1111/all.15471

No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**FIGURE 1**
EBV DNA copies/ml measured by in‐house real‐time PCR in throat washing samples of patients after SARS‐CoV‐2 infection with Long‐COVID fatigue (SARS‐CoV‐2 + LC) and without Long‐COVID fatigue (SARS‐CoV‐2 – LC). Bars indicate median plus interquartile range. Dotted line indicates the detection limit. Statistical analysis was performed by Mann–Whitney U test. A p‐value < 0.05 was considered significant.

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References

1. Sivan M, Taylor S. NICE guideline on long covid. BMJ. 2020;371:m4938. doi:10.1136/bmj.m4938 - DOI - PubMed
1. Zollner A, Koch R, Jukic A, et al. Postacute COVID‐19 is characterized by gut viral antigen persistence in inflammatory bowel diseases. Gastroenterology. 2022;163:495‐506.e8. doi:10.1053/j.gastro.2022.04.037 - DOI - PMC - PubMed
1. Lehner GF, Klein SJ, Zoller H, Peer A, Bellmann R, Joannidis M. Correlation of interleukin‐6 with Epstein‐Barr virus levels in COVID‐19. Crit Care. 2020;24:657. doi:10.1186/s13054-020-03384-6 - DOI - PMC - PubMed
1. Vietzen H, Zoufaly A, Traugott M, Aberle J, Aberle SW, Puchhammer‐Stöckl E. Deletion of the NKG2C receptor encoding KLRC2 gene and HLA‐E variants are risk factors for severe COVID‐19. Genet Med. 2021;23:963‐967. doi:10.1038/s41436-020-01077-7 - DOI - PMC - PubMed
1. Aberle SW, Puchhammer‐Stöckl E. Diagnosis of herpesvirus infections of the central nervous system. J Clin Virol. 2002;25:S79‐S85. doi:10.1016/s1386-6532(02)00037-9 - DOI - PubMed

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[1] Sivan M, Taylor S. NICE guideline on long covid. BMJ. 2020;371:m4938. doi:10.1136/bmj.m4938 - DOI - PubMed

[2] Sivan M, Taylor S. NICE guideline on long covid. BMJ. 2020;371:m4938. doi:10.1136/bmj.m4938 - DOI - PubMed

[3] Zollner A, Koch R, Jukic A, et al. Postacute COVID‐19 is characterized by gut viral antigen persistence in inflammatory bowel diseases. Gastroenterology. 2022;163:495‐506.e8. doi:10.1053/j.gastro.2022.04.037 - DOI - PMC - PubMed

[4] Zollner A, Koch R, Jukic A, et al. Postacute COVID‐19 is characterized by gut viral antigen persistence in inflammatory bowel diseases. Gastroenterology. 2022;163:495‐506.e8. doi:10.1053/j.gastro.2022.04.037 - DOI - PMC - PubMed

[5] Lehner GF, Klein SJ, Zoller H, Peer A, Bellmann R, Joannidis M. Correlation of interleukin‐6 with Epstein‐Barr virus levels in COVID‐19. Crit Care. 2020;24:657. doi:10.1186/s13054-020-03384-6 - DOI - PMC - PubMed

[6] Lehner GF, Klein SJ, Zoller H, Peer A, Bellmann R, Joannidis M. Correlation of interleukin‐6 with Epstein‐Barr virus levels in COVID‐19. Crit Care. 2020;24:657. doi:10.1186/s13054-020-03384-6 - DOI - PMC - PubMed

[7] Vietzen H, Zoufaly A, Traugott M, Aberle J, Aberle SW, Puchhammer‐Stöckl E. Deletion of the NKG2C receptor encoding KLRC2 gene and HLA‐E variants are risk factors for severe COVID‐19. Genet Med. 2021;23:963‐967. doi:10.1038/s41436-020-01077-7 - DOI - PMC - PubMed

[8] Vietzen H, Zoufaly A, Traugott M, Aberle J, Aberle SW, Puchhammer‐Stöckl E. Deletion of the NKG2C receptor encoding KLRC2 gene and HLA‐E variants are risk factors for severe COVID‐19. Genet Med. 2021;23:963‐967. doi:10.1038/s41436-020-01077-7 - DOI - PMC - PubMed

[9] Aberle SW, Puchhammer‐Stöckl E. Diagnosis of herpesvirus infections of the central nervous system. J Clin Virol. 2002;25:S79‐S85. doi:10.1016/s1386-6532(02)00037-9 - DOI - PubMed

[10] Aberle SW, Puchhammer‐Stöckl E. Diagnosis of herpesvirus infections of the central nervous system. J Clin Virol. 2002;25:S79‐S85. doi:10.1016/s1386-6532(02)00037-9 - DOI - PubMed

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Association between Epstein-Barr-Virus reactivation and development of Long-COVID fatigue

Affiliations

Association between Epstein-Barr-Virus reactivation and development of Long-COVID fatigue

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Conflict of interest statement

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