Amiodarone pulmonary toxicity presenting as bilateral exudative pleural effusions

Chest. 1987 Jul;92(1):179-82. doi: 10.1378/chest.92.1.179.


Therapy with the antiarrhythmic drug amiodarone has been associated with drug-related side effects. In addition to pulmonary fibrosing alveolitis, anecdotal reports have alluded to incidental pleural involvement associated with amiodarone. We describe an unusual manifestation of amiodarone-induced pulmonary toxicity in a patient with bilateral exudative pleural effusions and toxic involvement of other organs. We review amiodarone-associated pleural reactions reported in the literature.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amiodarone / toxicity*
  • Humans
  • Lung / drug effects*
  • Lung / pathology
  • Male
  • Middle Aged
  • Pleura / drug effects
  • Pleura / pathology
  • Pleural Effusion / chemically induced*
  • Pleurisy / chemically induced*


  • Amiodarone