Holding back: HLA-associated inhibition of NK cells gives HIV a leg up

Stephanie Jost

doi:10.1016/j.chom.2022.07.009

Holding back: HLA-associated inhibition of NK cells gives HIV a leg up

Cell Host Microbe. 2022 Aug 10;30(8):1072-1073. doi: 10.1016/j.chom.2022.07.009.

Author

Stephanie Jost¹

Affiliation

¹ Division of Innate and Comparative Immunology, Center for Human Systems Immunology, Department of Surgery, Duke University School of Medicine, Durham, NC, USA. Electronic address: stephanie.jost@duke.edu.

PMID: 35952644
DOI: 10.1016/j.chom.2022.07.009

Abstract

In this issue of Cell Host & Microbe, Li et al. unveil an association between HLA-B^∗46:01 and HIV disease progression in Asian populations. The distinct natural killer (NK) cell signature identified in individuals carrying HLA-B^∗46:01 strongly suggests that NK cell inhibition plays a role in loss of HIV control.

MeSH terms

HIV Infections*
HIV-1* / physiology
HLA-B Antigens
Humans
Killer Cells, Natural
Leg

Substances

HLA-B Antigens

Grants and funding

UM1 AI164570/AI/NIAID NIH HHS/United States