Lipoma and Its Doppelganger: The Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma

Surg Clin North Am. 2022 Aug;102(4):637-656. doi: 10.1016/j.suc.2022.04.006.


Lipomatous tumors are among the most common soft tissue lesions encountered by the general surgeon. Shared history and clinical presentation make differentiation between benign lipomas and low-grade liposarcomas a diagnostic dilemma. This article reviews the epidemiology, clinical history, diagnostic workup, management, natural history, and surveillance of benign lipomas and atypical lipomatous tumors/well-differentiated liposarcomas. Although it is important that aggressive, potentially malignant atypical lipomatous tumors and liposarcomas be managed in a multidisciplinary, preferably high-volume setting, it is equally as important for the nonspecialist general surgeon to be familiar with lipoma and its doppelganger-the well-differentiated liposarcoma.

Keywords: Diagnosis; Lipoma; Management; Review; Well-differentiated liposarcoma.

Publication types

  • Review

MeSH terms

  • Humans
  • Lipoma* / diagnosis
  • Lipoma* / pathology
  • Lipoma* / surgery
  • Liposarcoma* / diagnosis
  • Liposarcoma* / pathology
  • Liposarcoma* / surgery
  • Soft Tissue Neoplasms* / diagnosis
  • Soft Tissue Neoplasms* / pathology
  • Soft Tissue Neoplasms* / surgery