Benign Neurogenic Tumors

Surg Clin North Am. 2022 Aug;102(4):679-693. doi: 10.1016/j.suc.2022.04.007.


Neurogenic tumors arise from cells of the nervous system. These tumors can be found anywhere along the distribution of the sympathetic and parasympathetic nervous system and are categorized based on cell of origin: ganglion cell, paraganglion cell, and nerve sheath cells. Ganglion cell-derived tumors include neuroblastomas, ganglioneuroblastomas, and ganglioneuromas. Paraganglion cell-derived tumors include paragangliomas and pheochromocytomas. Nerve sheath cell-derived tumors include schwannomas (neurilemmomas), neurofibromas, and neurofibromatosis. Most of these are benign; however, they can cause local compressive symptoms. Surgery is the mainstay of treatment, if clinically indicated. Nonetheless, a thorough preoperative workup is essential, especially for catecholamine-secreting tumors.

Keywords: Benign neurogenic tumors; Neurofibroma; Paraganglioma; Pheochromocytoma; Schwannoma.

Publication types

  • Review

MeSH terms

  • Adrenal Gland Neoplasms* / diagnosis
  • Adrenal Gland Neoplasms* / surgery
  • Humans
  • Neurilemmoma* / diagnosis
  • Neurilemmoma* / pathology
  • Neurilemmoma* / surgery
  • Neurofibroma* / diagnosis
  • Neurofibroma* / pathology
  • Neurofibroma* / surgery
  • Peripheral Nervous System Neoplasms* / diagnosis
  • Peripheral Nervous System Neoplasms* / pathology
  • Peripheral Nervous System Neoplasms* / surgery