Ultra-processed foods and human health: from epidemiological evidence to mechanistic insights

Lancet Gastroenterol Hepatol. 2022 Dec;7(12):1128-1140. doi: 10.1016/S2468-1253(22)00169-8. Epub 2022 Aug 8.

Abstract

Epidemiological studies have suggested a role for ultra-processed foods in numerous chronic inflammatory diseases such as inflammatory bowel diseases and metabolic syndrome. Preclinical and clinical studies are accumulating to better decipher the effects of various aspects of food processing and formulation on the aetiology of chronic, debilitating inflammatory diseases. In this Review, we provide an overview of the current data that highlight an association between ultra-processed food consumption and various chronic diseases, with a focus on epidemiological evidence and mechanistic insights involving the intestinal microbiota.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diet* / adverse effects
  • Fast Foods / adverse effects
  • Food Handling
  • Humans
  • Metabolic Syndrome* / epidemiology
  • Metabolic Syndrome* / etiology