Mind the gap: Bromism secondary to internet-purchased supplements

Am J Emerg Med. 2022 Oct:60:229.e5-229.e6. doi: 10.1016/j.ajem.2022.08.005. Epub 2022 Aug 6.

Abstract

Bromism is an unusual syndrome characterized by a variety of nervous system impairments such as ataxia, confusion, and delusions. Contemporaneous cases are rare as therapeutic use of bromide-containing medications has declined, but bromides can still be obtained as unregulated dietary supplements. Bromism from dietary supplements is not well-described. We present a case of a 23-year-old male who was taking numerous supplements and developed bromism, characterized by ataxia, confusion, and persistent agitation. His laboratory evaluation revealed a large negative anion gap and a serum bromide level of 1200 mg/L (ref: 0-12 mg/L). He was treated with maintenance intravenous normal saline to promote excretion of the bromide ion and slowly returned to baseline over ten days. Bromism is an unusual but well-described constellation of neurologic impairments that presents insidiously and may be easily missed. The emergency physician should be aware of the dangers of bromide-containing dietary supplements and should educate patients taking these supplements of their risks.

Keywords: Bromism; Pseudohyperchloremia; Toxicology.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Ataxia
  • Bromides*
  • Confusion
  • Dietary Supplements / adverse effects
  • Humans
  • Internet
  • Male
  • Saline Solution*
  • Young Adult

Substances

  • Bromides
  • Saline Solution