Regulation of Autophagy Machinery in Magnaporthe oryzae

Int J Mol Sci. 2022 Jul 28;23(15):8366. doi: 10.3390/ijms23158366.


Plant diseases cause substantial loss to crops all over the world, reducing the quality and quantity of agricultural goods significantly. One of the world's most damaging plant diseases, rice blast poses a substantial threat to global food security. Magnaporthe oryzae causes rice blast disease, which challenges world food security by causing substantial damage in rice production annually. Autophagy is an evolutionarily conserved breakdown and recycling system in eukaryotes that regulate homeostasis, stress adaption, and programmed cell death. Recently, new studies found that the autophagy process plays a vital role in the pathogenicity of M. oryzae and the regulation mechanisms are gradually clarified. Here we present a brief summary of the recent advances, concentrating on the new findings of autophagy regulation mechanisms and summarize some autophagy-related techniques in rice blast fungus. This review will help readers to better understand the relationship between autophagy and the virulence of plant pathogenic fungi.

Keywords: Magnaporthe oryzae; appressorium; autophagosome; autophagy; autophagy-related techniques; pathogenesis; phagophore.

Publication types

  • Review

MeSH terms

  • Ascomycota* / metabolism
  • Autophagy / genetics
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Magnaporthe* / physiology
  • Oryza* / metabolism
  • Plant Diseases / microbiology


  • Fungal Proteins

Supplementary concepts

  • Pyricularia oryzae