Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment

Int J Mol Sci. 2022 Jul 28;23(15):8367. doi: 10.3390/ijms23158367.


Stroke is the leading cause of death and neurological disorders worldwide. However, diagnostic techniques and treatments for stroke patients are still limited for certain types of stroke. Intensive research has been conducted so far to find suitable diagnostic techniques and treatments, but so far there has been no success. In recent years, various studies have drawn much attention to the clinical value of utilizing the mechanism of exosomes, low toxicity, biodegradability, and the ability to cross the blood-brain barrier. Recent studies have been reported on the use of biomarkers and protective and recovery effects of exosomes derived from stem cells or various cells in the diagnostic stage after stroke. This review focuses on publications describing changes in diagnostic biomarkers of exosomes following various strokes and processes for various potential applications as therapeutics.

Keywords: exosome; exosome isolation; extracellular vesicles; hemorrhagic stroke; ischemic stroke; stroke.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Exosomes*
  • Hemorrhagic Stroke*
  • Humans
  • Stem Cells
  • Stroke* / diagnosis
  • Stroke* / therapy


  • Biomarkers

Grants and funding

This research was supported by grants from the Soonchunhyang University Fund and the Bio & Medical Technology Development Program of the National Research Foundation funded by the Korean government (NRF-2019M3E5D1A02069061 & 2020R1F1A1066362).