Case report: effect of umbilical cord mesenchymal stem cells on immunoglobulin A nephropathy after acute renal failure

Am J Transl Res. 2022 Jul 15;14(7):4855-4859. eCollection 2022.

Abstract

Immunoglobulin A nephropathy is an inflammatory, autoimmune condition that may lead to renal impairment in its most aggressive forms. In this case report, a 50-year-old male with acute renal failure was diagnosed with IgA nephropathy, having elevated creatinine levels (3.0 mg/dL) and hypertension. He received intravenous infusions of a total of 120 million umbilical cord-derived mesenchymal stem cells (UC-MSCs) and was followed-up for 6 months. No adverse events were reported during or after administration or any of the follow-up visits. Creatinine levels decreased to and remained normal (1.0 mg/dL) in the 6 months following treatment. Anti-hypertensive medications were no longer needed. UC-MSC administration was safe, well-tolerated, and beneficial for this patient with IgA nephropathy.

Keywords: IgA nephropathy; Mesenchymal stem cells; acute renal failure; creatinine; immunoglobulin A; kidney failure; stem cells; umbilical cord.

Publication types

  • Case Reports