Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder

Yanyan Wei; Tingting Wang; Guoguang Li; Junhui Feng; Lianbang Deng; Haiting Xu; Lu Yin; Jinbao Ma; Dongning Chen; Jingxu Chen

doi:10.3389/fpsyt.2022.941728

Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder

Front Psychiatry. 2022 Jul 26:13:941728. doi: 10.3389/fpsyt.2022.941728. eCollection 2022.

Authors

Yanyan Wei¹, Tingting Wang^{1

2}, Guoguang Li³, Junhui Feng⁴, Lianbang Deng¹, Haiting Xu¹, Lu Yin¹, Jinbao Ma⁵, Dongning Chen⁵, Jingxu Chen¹

Affiliations

¹ Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China.
² School of Mental Health, Bengbu Medical College, Bengbu, Anhui, China.
³ The Fourth People's Hospital of Liaocheng, Liaocheng, Shandong, China.
⁴ Jining Psychiatric Hospital, Jining, Shandong, China.
⁵ Beijing Tongren Hospital, Beijing, China.

Abstract

Background: The systemic immune-inflammation index (SII), system inflammation response index (SIRI), neutrophil/high-density lipoprotein (HDL) ratio (NHR), lymphocyte/HDL ratio (LHR), monocyte/HDL ratio (MHR), and platelet/HDL ratio (PHR) have been recently investigated as new markers for inflammation. The purpose of this research is to use large-scale clinical data to discuss and compare the predictive ability of the SII, SIRI, NHR, LHR, MHR, and PHR in patients with schizophrenia (SCZ) and bipolar disorder (BD), to investigate potential biomarkers.

Materials and methods: In this retrospective, naturalistic, cross-sectional study, we collected the hematological parameter data of 13,329 patients with SCZ, 4,061 patients with BD manic episodes (BD-M), and 1,944 patients with BD depressive episodes (BD-D), and 5,810 healthy subjects served as the healthy control (HC) group. The differences in the SII, SIRI, NHR, LHR, MHR, and PHR were analyzed, and a receiver operating characteristic (ROC) curve was used to analyze the diagnostic potential of these parameters.

Results: Compared with the HC group, the values of the SII, SIRI, NHR, LHR, MHR, and PHR and the levels of neutrophils, monocytes, and triglycerides (TG) were higher in SCZ and BD groups, and levels of platelets, cholesterol (CHO), HDL, low-density lipoprotein (LDL), and apoprotein B (Apo B) were lower in SCZ and BD groups. Compared to the BD group, the values of the SIRI, lymphocytes, monocytes, and HDL were lower and the values of the SII, NHR, PHR, and platelet were higher in the SCZ group. In contrast to the BD-D group, the values of the SII; SIRI; NHR; and MHR; and levels of neutrophils, monocytes, and platelets were higher in the BD-M group, and the levels of CHO, TG, LDL, and Apo B were lower in the BD-M group. The MHR and NHR were predictors for differentiating the SCZ group from the HC group; the SIRI, NHR, and MHR were predictors for differentiating the BD-M group from the HC group; and the MHR was a predictor for differentiating the BD-D group from the HC group. The combination model of the indicators improved diagnostic effectiveness.

Conclusion: Our study highlights the role of systemic inflammation in the pathophysiology of SCZ, BD-M, and BD-D, the association between inflammation and lipid metabolism, and these inflammation and lipid metabolism indicators showed different variation patterns in SCZ, BD-D, and BD-M.

Keywords: MHR; bipolar disorder; inflammation; lipid metabolism; schizophrenia.