Multi-omics analysis revealed the role of extracellular vesicles in hepatobiliary & pancreatic tumor

J Control Release. 2022 Aug 13;350:11-25. doi: 10.1016/j.jconrel.2022.08.010. Online ahead of print.


Liquid biopsy is rapidly growing into a hot research field due to its unique advantages of minimal invasiveness, and extracellular vesicle (EVs) are also expected to become an important pillar in the diagnostic technology system as a newly discovered active substance carrier. More and more research has highlighted the important contribution of EVs in the progress of tumor. Molecular changes during disease progression could be detected in EVs. However, the diagnostic applications of EVs are not generally understood. Combined with the characteristics of hepatobiliary and pancreatic tumor, we summarized the recent developments in various omics analysis of EVs. Furtherly, we explored the role of EVs in the early diagnosis of hepatobiliary and pancreatic tumors by multi-omics analysis.

Keywords: Early diagnosis; Extracellular vesicle; Hepatobiliary tumor; Liquid biopsy; Pancreatic tumor.

Publication types

  • Review