Creating a data commons: The INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT)

Kirk D Wyatt; Suzi Birz; Douglas S Hawkins; Veronique Minard-Colin; David A Rodeberg; Monika Sparber-Sauer; Gianni Bisogno; Ewa Koscielniak; Gian Luca De Salvo; Martin Ebinger; Johannes H M Merks; Suzanne L Wolden; Wei Xue; Samuel L Volchenboum; INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT)

doi:10.1002/pbc.29924

Creating a data commons: The INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT)

Pediatr Blood Cancer. 2022 Nov;69(11):e29924. doi: 10.1002/pbc.29924. Epub 2022 Aug 15.

Authors

Kirk D Wyatt¹, Suzi Birz², Douglas S Hawkins³, Veronique Minard-Colin⁴, David A Rodeberg⁵, Monika Sparber-Sauer^{6

7}, Gianni Bisogno⁸, Ewa Koscielniak^{6

7}, Gian Luca De Salvo⁹, Martin Ebinger¹⁰, Johannes H M Merks¹¹, Suzanne L Wolden¹², Wei Xue¹³, Samuel L Volchenboum²; INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT)¹

Affiliations

¹ Division of Pediatric Hematology/Oncology, Roger Maris Cancer Center, Sanford Health, Fargo, North Dakota, USA.
² Department of Pediatrics, University of Chicago, Chicago, Illinois, USA.
³ Division of Hematology/Oncology, Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, USA.
⁴ Department of Paediatric and Adolescent Oncology, Gustave-Roussy, Villejuif, France.
⁵ Division of Pediatric Surgery, University of Kentucky, Lexington, Kentucky, USA.
⁶ Klinikum der Landeshauptstadt Stuttgart, Olgahospital, Zentrum für Kinder-, Jugend -und Frauenmedizin, Pediatrie 5 (Pädiatrische Onkologie, Hämatologie, Immunologie) Stuttgart Cancer Center, Stuttgart, Germany.
⁷ Medical Faculty, University of Tübingen, Tübingen, Germany.
⁸ Hematology Oncology Division, Department of Women's and Children's Health, University Hospital of Padova, Padua, Italy.
⁹ Clinical Research Unit, Istituto Oncologico Veneto IOV IRCCS, Padua, Italy.
¹⁰ Department Pediatric Hematology/Oncology, Children's University Hospital, Eberhard Karls University of Tuebingen, Tübingen, Germany.
¹¹ Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
¹² Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
¹³ Department of Biostatistics, Children's Oncology Group Statistics and Data Center, University of Florida, Gainesville, Florida, USA.

Abstract

In this article, we will discuss the genesis, evolution, and progress of the INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT), which aims to foster international research and collaboration focused on pediatric soft tissue sarcoma. We will begin by highlighting the current state of clinical research for pediatric soft tissue sarcomas, including rhabdomyosarcoma and non-rhabdomyosarcoma soft tissue sarcoma. We will then explore challenges and research priorities, describe the development of INSTRuCT, and discuss how the consortium aims to address key research priorities.

Keywords: data aggregation; pediatrics; sarcoma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Child
Humans
Rhabdomyosarcoma*
Sarcoma* / therapy
Soft Tissue Neoplasms* / therapy

Abstract

Publication types

MeSH terms

Grants and funding