Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial

Am J Gastroenterol. 2022 Oct 1;117(10):1714-1717. doi: 10.14309/ajg.0000000000001931. Epub 2022 Aug 12.


Introduction: The aim of this study was to determine the effectiveness of prune juice on chronic constipation.

Methods: We conducted a double-blind, randomized, placebo-controlled trial in Japanese subjects with chronic constipation.

Results: Prune intake significantly decreased hard and lumpy stools while increasing normal stool and not increasing loose and watery stools. Prune intake also ameliorated subjective complaints of constipation and hard stools, without alteration of flatulence, diarrhea, loose stools, or urgent need for defecation. There were no adverse events or laboratory abnormalities of liver or renal function after prune intake.

Discussion: Prune juice exerted an effective and safe natural food therapy for chronic constipation.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Constipation / drug therapy
  • Defecation
  • Diarrhea / drug therapy
  • Dietary Fiber
  • Double-Blind Method
  • Feces
  • Humans
  • Pectins
  • Polyphenols*
  • Sorbitol*


  • Dietary Fiber
  • Polyphenols
  • Sorbitol
  • Pectins

Associated data

  • UMIN-CTR/UMIN000041384