Sleep disorder as a clinical risk factor of major depression: associated with cognitive impairment

Ru Feng Chen; Yuan Cai; Zhen Hua Zhu; Wen Long Hou; Peng Chen; Jing Wang; Yi Ming Jia; Zheng Bao Zhu; Yong Hong Zhang; Lu Yang Tao; Jia Wei Wu; Jianping Zhang; Huiping Zhang; Zhi Xin Wang; Qiu Fang Jia; Li Hui

doi:10.1016/j.ajp.2022.103228

Sleep disorder as a clinical risk factor of major depression: associated with cognitive impairment

Asian J Psychiatr. 2022 Oct:76:103228. doi: 10.1016/j.ajp.2022.103228. Epub 2022 Aug 9.

Authors

Ru Feng Chen¹, Yuan Cai¹, Zhen Hua Zhu¹, Wen Long Hou¹, Peng Chen¹, Jing Wang¹, Yi Ming Jia², Zheng Bao Zhu², Yong Hong Zhang², Lu Yang Tao¹, Jia Wei Wu¹, Jianping Zhang³, Huiping Zhang⁴, Zhi Xin Wang⁵, Qiu Fang Jia⁶, Li Hui⁷

Affiliations

¹ Research Center of Biological Psychiatry, Suzhou Guangji Hospital, School of Basic Medicine and Biological Sciences, Suzhou Medical College of Soochow University, Suzhou 215137, Jiangsu Province, PR China.
² Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Suzhou Medical College of Soochow University, Suzhou 215123, Jiangsu Province, PR China.
³ Department of Psychiatry, Weill Cornell Medical College, Cornell University, New York, NY 10605, USA.
⁴ Departments of Psychiatry and Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA 02118-2526, USA.
⁵ Research Center of Biological Psychiatry, Suzhou Guangji Hospital, School of Basic Medicine and Biological Sciences, Suzhou Medical College of Soochow University, Suzhou 215137, Jiangsu Province, PR China. Electronic address: zhixinwang@suda.edu.cn.
⁶ Research Center of Biological Psychiatry, Suzhou Guangji Hospital, School of Basic Medicine and Biological Sciences, Suzhou Medical College of Soochow University, Suzhou 215137, Jiangsu Province, PR China. Electronic address: 15774374554@qq.com.
⁷ Research Center of Biological Psychiatry, Suzhou Guangji Hospital, School of Basic Medicine and Biological Sciences, Suzhou Medical College of Soochow University, Suzhou 215137, Jiangsu Province, PR China. Electronic address: huili004100@126.com.

PMID: 35973338
DOI: 10.1016/j.ajp.2022.103228

Abstract

Background: This research aims explored the sleep disorder (SD) role in major depressive disorder (MDD), and the SD influencing their cognition.

Methods: 372 MDD patients and 457 healthy controls (HCs) were enrolled.

Results: Patients increased a 38.88 times SD risk compared with HCs. In patients, visuospatial/constructional score was lower in SD than non-SD, and PSQI score was negatively associated with visuospatial/constructional score of SD. In SD and non-SD, RBANS scores were lower in MDD than HCs, excepted for visuospatial/constructional in non-SD.

Conclusion: The SD as a MDD risk factor, has more serious visuospatial/constructional impairment alleviated via improving sleep/depression in patients.

Keywords: Cognition; Major depressive disorder; Prevalence; Risk factor; Sleep.

MeSH terms

Cognition
Cognitive Dysfunction* / complications
Depression
Depressive Disorder, Major* / complications
Depressive Disorder, Major* / psychology
Humans
Neuropsychological Tests
Risk Factors
Sleep Wake Disorders* / complications