Redox-based disruption of cellular hormesis and promotion of degenerative pathways: perspectives on ageing processes

J Gerontol A Biol Sci Med Sci. 2022 Aug 17;glac167. doi: 10.1093/gerona/glac167. Online ahead of print.

Abstract

The present work aims to link the redox and cell-centric theories of chronic processes in human biology, focusing on ageing. A synthetic overview of cellular redox pathways will be integrated by the concept of hormesis, which disruption leads to several physiopathological processes. The onset of age-related diseases due to the restriction of homeodynamic capacity will be herein considered in a redox fashion. Up-to-date arguments on hormetic agents, such as geroprotectors, dietary interventions, and physical exercise are refining the presented theoretical framework, integrated by insights from extracellular vesicles, microbiota, pollutants, and timing mechanisms. The broad concepts of exposome encompass the redox-based alteration of cellular hormesis for providing meaningful perspectives on redox biogerontology.

Keywords: Hormetic agents; RONS; biogerontology; exposome; redox network.