Efficacy of MitoHeal® supplementation on adult skin quality and patient satisfaction: a randomized, double-blind, placebo-controlled, pilot study

Clin Exp Dermatol. 2022 Dec;47(12):2269-2272. doi: 10.1111/ced.15371. Epub 2022 Oct 4.


Aim: Polyphenols, the most abundant natural biochemicals found in fruits, vegetables seeds, red wine, cocoa, coffee and spices, may have cosmetic and health effects.

Methods: This was a 1-month randomized, placebo-controlled study, approved by the institutional review board. In total, 40 adults (mean age 44.65 years) were randomized to one of three groups: MitoHeal® 500 mg/day, MitoHeal® 1000 mg/day or placebo drink. Measurements were expert rating of professional photos of skin quality and patient self-reported skin satisfaction at Days 0 and 30.

Results: The photographs and self-report assessments revealed that, compared with placebo, MitoHeal supplementation resulted in improvements in skin quality and patient satisfaction from Day 0 to Day 30, with a dose-response relationship often evidenced (P < 0.05). No adverse events were reported.

Conclusion: Pilot data revealed that MitoHeal supplementation might be effective for improving skin quality and patient satisfaction. Larger sample sizes and trial durations are needed to determine the effects of MitoHeal supplementation on beauty and overall health.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Dietary Supplements*
  • Double-Blind Method
  • Humans
  • Patient Satisfaction*
  • Pilot Projects

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