Evolution and Transmission of Cefiderocol-Resistant Acinetobacter baumannii During an Outbreak in the Burn Intensive Care Unit

Clin Infect Dis. 2023 Feb 8;76(3):e1261-e1265. doi: 10.1093/cid/ciac647.

Abstract

We report on 11 critically ill burn patients treated with cefiderocol for carbapenem-resistant Acinetobacter baumannii infections. Clinical success was achieved in 36% and complicated by treatment-emergent resistance and interpatient transmission of cefiderocol-resistant A. baumannii. Resistant isolates harbored disrupted pirA and piuA genes that were not disrupted among susceptible isolates.

Keywords: antibiotic resistance; burn; carbapenem-resistant Acinetobacter baumannii; cefiderocol; whole-genome sequencing.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acinetobacter Infections* / drug therapy
  • Acinetobacter Infections* / epidemiology
  • Acinetobacter baumannii* / genetics
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Cefiderocol
  • Disease Outbreaks
  • Drug Resistance, Multiple, Bacterial / genetics
  • Humans
  • Intensive Care Units
  • Microbial Sensitivity Tests

Substances

  • Anti-Bacterial Agents