3D-printed microneedle arrays for drug delivery

J Control Release. 2022 Oct;350:933-948. doi: 10.1016/j.jconrel.2022.08.022. Epub 2022 Sep 26.


Microneedle arrays provide an efficient tool for transdermal drug delivery in a minimally invasive and painless manner, showing great potential applications in medicine. However, it remains challenging to fabricate the desired microneedle arrays, because of their micron-scale size and fine structure. Novel manufacturing technologies are very wanted for the development of microneedle arrays, which would solidly advance the clinical translation of microneedle arrays. 3D printing technology is a powerful manufacturing technology with superiority in fabricating personalized and complex structures. Currently, 3D printing technology has been employed to fabricate microneedle arrays, which could push more microneedle arrays into clinic and inspire the development of future microneedle arrays. This work reviews the art of 3D printing microneedle arrays, the benefits of fabricating microneedle arrays with 3D printing, and the considerations for clinical translation of 3D-printed microneedle arrays. This work provides an overview of the current 3D-printed microneedle arrays in drug delivery.

Keywords: 3D printing; Drug delivery; Microneedle arrays; Product development.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Drug Delivery Systems*
  • Pharmaceutical Preparations / chemistry
  • Printing, Three-Dimensional*


  • Pharmaceutical Preparations