The alprazolam to clonazepam switch for the treatment of panic disorder

J Clin Psychopharmacol. 1987 Jun;7(3):175-8.


Forty-eight consecutive patients treated for panic disorder with alprazolam, but with presumed interdose anxiety symptoms, were switched to clonazepam. Forty-one patients made the "switch" according to a protocol, and 82% rated clonazepam "better" because of decreased frequency of administration and lack of interdose anxiety. Both medications seemed effective for panic disorder at comparable doses, and the authors describe how to switch from alprazolam to clonazepam when interdose anxiety is a concern.

Publication types

  • Comparative Study

MeSH terms

  • Alprazolam / therapeutic use*
  • Anxiety Disorders / drug therapy*
  • Clonazepam / therapeutic use*
  • Fear / drug effects*
  • Humans
  • Panic / drug effects*


  • Clonazepam
  • Alprazolam