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. 2022 Dec;44(6):2785-2800.
doi: 10.1007/s11357-022-00642-z. Epub 2022 Aug 17.

Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study

Vaka Valsdóttir  1   2 , Brynja Björk Magnúsdóttir  3   4 , Milan Chang  5 , Sigurdur Sigurdsson  6 , Vilmundur Gudnason  6   7 , Lenore J Launer  8 , María K Jónsdóttir  3   4
Affiliations

Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study

Vaka Valsdóttir et al. Geroscience. 2022 Dec.

Abstract

The paper aimed to compare how factors previously identified as predictive factors for cognitive decline and dementia related to cognitive performance on the one hand and brain health on the other. To that aim, multiple linear regression was applied to the AGES-Reykjavik study epidemiological data. Additionally, a regression analysis was performed for change in cognition over 5 years, using the same exposure factors. The study ran from 2002 to 2011, and the sample analyzed included 1707 participants between the ages of 66 and 90. The data contains MR imaging, cognitive testing, background data, and physiological measurements. Overall, we conclude that risk factors linked to dementia relate differently to cognition and brain health. Mobility, physical strength, alcohol consumption, coronary artery disease, and hypertension were associated with cognition and brain volume. Smoking, depression, diabetes, and body fat percentage were only associated with brain volume, not cognitive performance. Modifiable factors previously linked to cognitive reserve, such as educational attainment, participation in leisure activities, multilingualism and good self-reported health, were associated with cognitive function but did not relate to brain volume. These findings show that, within the same participant pool, cognitive reserve proxy variables have a relationship with cognitive performance but have no association with relative brain volume measured simultaneously.

Keywords: AGES-Reykjavik study; Brain health; Brain pathology; Cognitive aging; Cognitive performance; Cognitive reserve.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of the participant selection for the primary analysis
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References

    1. Depp CA, Harmell A, Vahia IV. Successful cognitive aging. In: Behavioral neurobiology of aging. 2011. pp. 35–50. 10.1007/7854_2011_158. - PubMed
    1. World Health Organization. Risk reduction of cognitive decline and dementia: WHO guidelines. World Health Organization, Geneva, 2019. [Online]. Available: https://apps.who.int/iris/bitstream/handle/10665/312180/9789241550543-en...Accessed 16 May 2019 - PubMed
    1. Cutler SJ. Worries about getting Alzheimer’s: who’s concerned? Am J Alzheimers Dis Other Demen. 2015;30(6):591–598. doi: 10.1177/1533317514568889. - DOI - PubMed
    1. Hongisto K, et al. Quality of Life in relation to neuropsychiatric symptoms in Alzheimer’s disease: 5-year prospective ALSOVA cohort study. Int J Geriatr Psychiatry. 2018;33(1):47–57. doi: 10.1002/gps.4666. - DOI - PubMed
    1. Alzheimer’s Association. 2015 Alzheimer’s disease facts and figures. Alzheimers Dement. 2015;11(3):332–384. 10.1016/j.jalz.2015.02.003. - PubMed

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