Spinal Obstruction-Related vs. Craniocervical Junction-Related Syringomyelia: A Comparative Study

Chenghua Yuan; Jian Guan; Yueqi Du; Zeyu Fang; Xinyu Wang; Qingyu Yao; Can Zhang; Shanhang Jia; Zhenlei Liu; Kai Wang; Wanru Duan; Xingwen Wang; Zuowei Wang; Hao Wu; Zan Chen; Fengzeng Jian

doi:10.3389/fneur.2022.900441

Spinal Obstruction-Related vs. Craniocervical Junction-Related Syringomyelia: A Comparative Study

Front Neurol. 2022 Aug 1:13:900441. doi: 10.3389/fneur.2022.900441. eCollection 2022.

Authors

Chenghua Yuan^{1

2

3

4

5}, Jian Guan^{1

2

3

4

5}, Yueqi Du^{1

2

3

4

5}, Zeyu Fang^{1

2

3

4

5}, Xinyu Wang^{1

2

3

4

5}, Qingyu Yao^{1

2

3

4

5}, Can Zhang^{1

2

3

4

5}, Shanhang Jia^{1

2

3

4

5}, Zhenlei Liu^{1

2

3

4

5}, Kai Wang^{1

2

3

4

5}, Wanru Duan^{1

2

3

4

5}, Xingwen Wang^{1

2

3

4

5}, Zuowei Wang^{1

2

3

4

5}, Hao Wu^{1

2

3

4

5}, Zan Chen^{1

2

3

4

5}, Fengzeng Jian^{1

2

3

4

5}

Affiliations

¹ Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
² Spine Center, China International Neuroscience Institute (CHINA-INI), Beijing, China.
³ Laboratory of Spinal Cord Injury and Functional Reconstruction, Xuanwu Hospital, Capital Medical University, Beijing, China.
⁴ Research Center of Spine and Spinal Cord, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China.
⁵ National Center for Neurological Disorders, Beijing, China.

Abstract

Background: No prior reports have focused on spinal cord injury (SCI) characteristics or inflammation after destruction of the blood-spinal cord barrier by syringomyelia. This study aimed to determine the differences in syringomyelia-related central SCI between craniocervical junction (CCJ) syringomyelia and post-traumatic syringomyelia (PTS) before and after decompression.

Methods: In all, 106 CCJ, 26 CCJ revision and 15 PTS patients (mean history of symptoms, 71.5 ± 94.3, 88.9 ± 85.5, and 32.3 ± 48.9 months) between 2015 and 2019 were included. The symptom course was analyzed with the American Spinal Injury Association ASIA and Klekamp-Samii scoring systems, and neurological changes were analyzed by the Kaplan-Meier statistics. The mean follow-up was 20.7 ± 6.2, 21.7 ± 8.8, and 34.8 ± 19.4 months.

Results: The interval after injury was longer in the PTS group, but the natural history of syringomyelia was shorter (p = 0.0004 and 0.0173, respectively). The initial symptom was usually paraesthesia (p = 0.258), and the other main symptoms were hypoesthesia (p = 0.006) and abnormal muscle strength (p = 0.004), gait (p < 0.0001), and urination (p < 0.0001). SCI associated with PTS was more severe than that associated with the CCJ (p = 0.003). The cavities in the PTS group were primarily located at the thoracolumbar level, while those in the CCJ group were located at the cervical-thoracic segment at the CCJ. The syrinx/cord ratio of the PTS group was more than 75% (p = 0.009), and the intradural adhesions tended to be more severe (p < 0.0001). However, there were no significant differences in long-term clinical efficacy or peripheral blood inflammation markers (PBIMs) except for the red blood cell (RBC) count (p = 0.042).

Conclusion: PTS tends to progress faster than CCJ-related syringomyelia. Except for the RBC count, PBIMs showed no value in distinguishing the two forms of syringomyelia. The predictive value of the neutrophil-to-lymphocyte ratio for syringomyelia-related inflammation was negative except in the acute phase.

Keywords: CSF; biomarker; decompression; spinal cord injury; syringomyelia.