Shedding light on current trends in molecular optogenetics

Curr Opin Chem Biol. 2022 Oct;70:102196. doi: 10.1016/j.cbpa.2022.102196. Epub 2022 Aug 18.


Molecular optogenetics is a highly dynamic research field. In the past two years, the field was characterized by the development of new allosteric switches as well as the forward integration of optogenetics research towards application. Further, two areas of research have significantly gathered momentum, the use of optogenetics to control liquid-liquid phase separation as well as the application of optogenetic tools in the extracellular space. Here, we review these areas and discuss future directions.

Keywords: Extracellular optogenetics; Liquid–liquid phase separation; Molecular photoswitches; Non-opsin-based optogenetics.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Optogenetics* / trends
  • Research / trends