Antiviral death punch by ADP-ribosylating bacterial toxins

Aisylu Shaidullina; Alexander Harms

doi:10.1016/j.tim.2022.08.009

Antiviral death punch by ADP-ribosylating bacterial toxins

Trends Microbiol. 2022 Oct;30(10):920-921. doi: 10.1016/j.tim.2022.08.009. Epub 2022 Aug 18.

Authors

Aisylu Shaidullina¹, Alexander Harms²

Affiliations

¹ Biozentrum, University of Basel, Basel, Switzerland.
² Biozentrum, University of Basel, Basel, Switzerland. Electronic address: alexander.harms@unibas.ch.

PMID: 35989163
DOI: 10.1016/j.tim.2022.08.009

Abstract

Toxin-antitoxin systems can defend bacteria against phages by shutting down infected cells, but the links between their molecular mechanisms and biological functions have remained underexplored. LeRoux et al. now show how the DNA-targeting ADP-ribosylation activity of DarTG impairs phage replication but is overcome by dedicated viral inhibitors and evolved tolerance.

Keywords: ADP-ribosylation; antiviral defense; bacterial immunity; bacteriophage; toxin–antitoxin system.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adenosine Diphosphate
Antiviral Agents
Bacterial Toxins*
Bacteriophages*

Substances

Antiviral Agents
Bacterial Toxins
Adenosine Diphosphate