Low-dose proton radiotherapy for pediatric choroidal hemangioma: A case series

Pediatr Blood Cancer. 2022 Dec;69(12):e29925. doi: 10.1002/pbc.29925. Epub 2022 Aug 21.


Management of pediatric choroidal hemangioma complicated by large exudative retinal detachment can be challenging, with few options available. Limited data have been published on outcomes following proton radiotherapy (PRT) for management of these patients. In this retrospective case series, nine patients were treated with a low-dose PRT regimen of 20 Gy(relative biological effectiveness [RBE]) in 10 fractions, and two were treated with 15 Gy(RBE) in four fractions. Visual acuity improved in seven patients (64%) and remained stable in the remaining four (36%). In patients with imaging follow-up (10 patients), subretinal fluid resolved in nine patients (90%) and tumor thickness decreased or remained stable in 10 (100%). Complications were observed in eight of 11 patients (73%). One patient developed grade 2 cataract; otherwise, no grade ≥2 complications were observed.

Keywords: Sturge-Weber syndrome; choroidal hemangioma; diffuse choroidal hemangioma; pediatric oncology; proton radiotherapy; vascular anomaly.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Child
  • Choroid Neoplasms* / complications
  • Choroid Neoplasms* / pathology
  • Choroid Neoplasms* / radiotherapy
  • Hemangioma* / pathology
  • Humans
  • Protons
  • Retrospective Studies
  • Sturge-Weber Syndrome* / complications
  • Sturge-Weber Syndrome* / radiotherapy


  • Protons