Pregnancy among patients with systemic lupus erythematosus receiving immunosuppressive therapy

J Rheumatol. 1987 Apr;14(2):252-8.

Abstract

We evaluated retrospectively the effect of superimposed pregnancy upon the course of systemic lupus erythematosus (SLE) in patients receiving glucocorticoids or azathioprine at conception. About equal numbers of flares (10 vs 12) occurred among 22 pregnant patients with lupus and 22 nonpregnant control patients with lupus matched by disease duration and prior organ system involvement. Pregnancy per se did not appear to accelerate SLE in patients receiving immunosuppressive therapy.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Azathioprine / therapeutic use
  • Creatine / blood
  • Female
  • Fertilization
  • Humans
  • Immunosuppression*
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Erythematosus, Systemic / physiopathology
  • Lupus Erythematosus, Systemic / therapy*
  • Prednisone / therapeutic use
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Pregnancy Complications / physiopathology
  • Pregnancy Complications / therapy*
  • Time Factors

Substances

  • Azathioprine
  • Creatine
  • Prednisone