Frizzled does not get bent out of shape by Wnt

Sci Signal. 2022 Aug 23;15(748):eadd3535. doi: 10.1126/scisignal.add3535. Epub 2022 Aug 23.


Ligands of the Wnt family activate the Frizzled-LRP5/6 receptor complex to initiate intracellular signaling. In this issue of Science Signaling, Mahoney et al. reveal a Wnt-stimulated positive feedback loop that involves local production of the lipid phosphatidylinositol(4,5)bisphosphate [PI(4,5)P2], which promotes Dishevelled recruitment and additional PI(4,5)P2 production, to facilitate LRP5/6 phosphorylation.

Publication types

  • Review
  • Comment

MeSH terms

  • Frizzled Receptors*
  • Ligands
  • Signal Transduction* / physiology
  • beta Catenin / metabolism


  • Frizzled Receptors
  • Ligands
  • beta Catenin