An Overview of Aptamer-Based Sensor Platforms for the Detection of Bisphenol-A

Crit Rev Anal Chem. 2022 Aug 24;1-22. doi: 10.1080/10408347.2022.2113359. Online ahead of print.


Endocrine disruptive compounds are natural or anthropogenic environmental micropollutants that alter the function of the endocrine system ultimately damaging the metabolism. Bisphenol A (BPA) is the most common of these pollutants and it is often used in epoxy coatings and polycarbonates as a plasticizer. Therefore, monitoring BPA levels in different environments is very important and challenging. In recent years, an increasing number of BPA detection methods have been proposed. This article presents a critical review of aptamer-based electrochemical, fluorescence-based, colorimetric, and several other BPA detection platforms published in the last decade. Furthermore, a statistical evaluation has been made using principle component analysis showing analytical performance parameters do not create very different clusters. Comparisons to other BPA detection methods are also presented so that the reader has an overall literature overview.

Keywords: Bisphenol A; aptamers; biosensor; endocrine disruptive compounds.

Publication types

  • Review