N(6)-methyladenosine modification: A vital role of programmed cell death in myocardial ischemia/reperfusion injury

Abstract

N(6)-methyladenosine (m⁶A) modification is closely associated with myocardial ischemia/reperfusion injury (MIRI). As the most common modification among RNA modifications, the reversible m⁶A modification is processed by methylase ("writers") and demethylase ("erasers"). The biological effects of RNA modified by m⁶A are regulated under the corresponding RNA binding proteins (RBPs) ("readers"). m⁶A modification regulates the whole process of RNA, including transcription, processing, splicing, nuclear export, stability, degradation, and translation. Programmed cell death (PCD) is a regulated mechanism that maintains the internal environment's stability. PCD plays an essential role in MIRI, including apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis. However, the relationship between PCD modified with m⁶A and MIRI is still not clear. This review summarizes the regulators of m⁶A modification and their bioeffects on PCD in MIRI.

Keywords: Myocardial ischemia/reperfusion injury; Programmed cell death; m(6)A modification.