Genome sequence of the aurodox-producing bacterium Streptomyces goldiniensis ATCC 21386

Rebecca E McHugh; John T Munnoch; Andrew J Roe; Paul A Hoskisson

doi:10.1099/acmi.0.000358

Genome sequence of the aurodox-producing bacterium Streptomyces goldiniensis ATCC 21386

Access Microbiol. 2022 Aug 19;4(5):acmi000358. doi: 10.1099/acmi.0.000358. eCollection 2022 Aug.

Authors

Rebecca E McHugh^{1

2}, John T Munnoch¹, Andrew J Roe², Paul A Hoskisson¹

Affiliations

¹ Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK.
² Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.

Abstract

We report the genome sequence of Streptomyces goldiniensis ATCC 21386, a strain which produces the anti-bacterial and anti-virulence polyketide, aurodox. The genome of S. goldiniensis ATCC 21386 was sequenced using a multiplatform hybrid approach, revealing a linear genome of ~10 Mbp with a G+C content of 71%. The genome sequence revealed 36 putative biosynthetic gene clusters (BGCs), including a large region of 271 Kbp that was rich in biosynthetic capability. The genome sequence is deposited in DDBJ/EMBL/GenBank with the accession number PRJNA602141.

Keywords: Aurodox; Streptomyces; antimicrobial; elfamycin; genome.

Associated data

figshare/10.6084/m9.figshare.19487693.v2