Use of sodium glucose co-transporter 2 inhibitors in acute heart failure: a practical guidance

ESC Heart Fail. 2022 Dec;9(6):4344-4347. doi: 10.1002/ehf2.14090. Epub 2022 Aug 25.

Abstract

Aims: Heart failure (HF) is the most frequent cause of hospital admission among patients 65 years or older. Patients hospitalized for acutely decompensated chronic HF and 'de novo' acute heart failure (AHF) continue to experience unacceptably high post-discharge readmission and mortality rates.

Methods and results: Until recently, trials had failed to improve outcome in patients with AHF irrespective of ejection fraction with exception of sodium-glucose co-transporter 2 inhibitors (SGLT2i) that improved clinical outcomes in patients hospitalized for AHF in the Study to Test the Effect of Empagliflozin in Patients Who Are in Hospital for Acute Heart Failure (EMPULSE) and in the Effect of Sotagliflozin on Cardiovascular Events in Patients With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF) trials.

Conclusions: This document reviews the potential utility of SGLT2i in patients hospitalized for AHF.

Keywords: Acute heart failure; Outcomes; Sodium-glucose co-transporter 2 inhibitors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Aftercare
  • Diabetes Mellitus, Type 2* / complications
  • Diabetes Mellitus, Type 2* / drug therapy
  • Glucose
  • Heart Failure* / complications
  • Heart Failure* / drug therapy
  • Humans
  • Patient Discharge
  • Sodium
  • Sodium-Glucose Transporter 2 Inhibitors* / therapeutic use
  • Symporters*

Substances

  • Sodium-Glucose Transporter 2 Inhibitors
  • Symporters
  • Glucose
  • Sodium