Effects of Dietary Lanthanum Chloride on Growth Performance, Hematology and Serum Biochemistry of Juvenile Clarias gariepinus Catfish Fed Diets Amended with Mixtures of Aflatoxin B1 and Fumonisin B1

Toxins (Basel). 2022 Aug 14;14(8):553. doi: 10.3390/toxins14080553.

Abstract

This study aimed to determine the effects of dietary lanthanum chloride on the growth and health performance of juvenile Clarias gariepinus when fed diets experimentally contaminated with mixtures of aflatoxin B1 and fumonisin B1. A control diet, (mycotoxin free, diet A), mycotoxin contaminated (diet B), and two mycotoxin-contaminated diets amended with lanthanum chloride (200 mg/kg, diet C; and 400 mg/kg, diet D), were fed to 450 fish divided equally into five groups (each with three replicates) for 56 days. The fish were randomly sampled at the time points: day 7, 28 and day 56 for the zootechnical, hematological and serum biochemical evaluations. The fish fed the diets amended with lanthanum chloride exhibited significantly (p < 0.05) better performance indices compared with the fish fed only the mycotoxin-contaminated diet. Lanthanum chloride elicited significant (p < 0.05) increases in erythrocytes and leucocytes count and significant (p < 0.05) reduction in serum transaminase, alkaline phosphatase, lactate dehydrogenase activities, urea and uric acid concentrations in the fish fed the diets contaminated with mixtures of aflatoxin B1 and fumonisin B1. The study indicates that juvenile Clarias gariepinus may be beneficially cultured with mycotoxin-contaminated grains amended with 200 to 400 mg/kg lanthanum chloride.

Keywords: Clarias gariepinus; aflatoxin B1; fumonisin B1; hematology; lanthanum chloride; serum biochemistry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aflatoxin B1 / toxicity
  • Animal Feed / analysis
  • Animals
  • Catfishes*
  • Diet / veterinary
  • Fumonisins
  • Hematology*
  • Lanthanum
  • Mycotoxins*

Substances

  • Fumonisins
  • Mycotoxins
  • lanthanum chloride
  • fumonisin B1
  • Lanthanum
  • Aflatoxin B1

Grant support

This research was funded by The University of Abuja Institutional Based Research Grant, grant number TETFUND/DESS/UNI/ABUJA/RP/VOL. 2 and the APC was funded by TETFUND/DESS/UNI/ABUJA/RP/VOL. 2.