Skin-Aging Pigmentation: Who Is the Real Enemy?

Cells. 2022 Aug 16;11(16):2541. doi: 10.3390/cells11162541.


Skin aging is induced and sustained by chronological aging and photoaging. Aging skin pigmentation such as mottled pigmentation (senile lentigo) and melasma are typical signs of photoaging. The skin, like other human organs, undergoes cellular senescence, and senescent cells in the skin increase with age. The crosstalk between melanocytes as pigmentary cells and other adjacent types of aged skin cells such as senescent fibroblasts play a role in skin-aging pigmentation. In this review, we provide an overview of cellular senescence during the skin-aging process. The discussion also includes cellular senescence related to skin-aging pigmentation and the therapeutic potential of regulating the senescence process.

Keywords: aging; cellular senescence; fibroblasts; keratinocytes; melanocytes; senescence; skin pigmentation.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aging / physiology
  • Cellular Senescence / physiology
  • Humans
  • Melanocytes
  • Skin Aging*
  • Skin Pigmentation*

Grants and funding

This study was supported by the National Research Foundation of Korea (NRF-2020R1A6A1A03043539, NRF-2020M3A9D8037604).