Immunomodulatory Properties of Polysaccharides from Lentinula edodes

Int J Mol Sci. 2022 Aug 11;23(16):8980. doi: 10.3390/ijms23168980.


Lentinula edodes (Berk.) Pegler, also known as shiitake mushroom, is a popular edible macrofungus and a source of numerous bioactive substances with multiple beneficial health effects. L. edodes-derived polysaccharides are the most valuable compounds, with anticancer, antioxidant, antimicrobial, and immunomodulatory properties. It has been demonstrated that their biological activity depends on the extraction method, which affects monosaccharide composition, molecular weight, branching degrees, and helical conformation. In this review, we discuss the immunomodulatory properties of various polysaccharides from L. edodes in animal models and in humans.

Keywords: Lentinula edodes; immunomodulation; polysaccharide.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents*
  • Antioxidants
  • Humans
  • Molecular Weight
  • Polysaccharides / pharmacology
  • Shiitake Mushrooms*


  • Antineoplastic Agents
  • Antioxidants
  • Polysaccharides

Grants and funding

This research received no external funding.