Connective tissue disease and sarcoidosis: a true association or a secondary granulomatous reaction?

Lloyd Steele; Maria Bickerstaff; Sharanpal Jeetle; Anshoo Sahota; Thiviyani Maruthappu; Malvina Cunningham

doi:10.1111/ced.15330

Connective tissue disease and sarcoidosis: a true association or a secondary granulomatous reaction?

Clin Exp Dermatol. 2022 Nov;47(11):2065-2068. doi: 10.1111/ced.15330. Epub 2022 Aug 27.

Authors

Lloyd Steele^{1

2}, Maria Bickerstaff³, Sharanpal Jeetle⁴, Anshoo Sahota¹, Thiviyani Maruthappu¹, Malvina Cunningham¹

Affiliations

¹ Departments of Dermatology Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University of London, London, UK.
² Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University of London, London, UK.
³ Rheumatology, The Royal London Hospital, Barts Health NHS Trust, London, UK.
⁴ Histopathology, The Royal London Hospital, Barts Health NHS Trust, London, UK.

PMID: 36029143
DOI: 10.1111/ced.15330

Abstract

Sarcoidosis occurs much more commonly in cohorts of connective tissue disease (1%) compared to the general population (0.01-0.04%). We present a case of concomitant connective tissue disease and cutaneous sarcoidal granulomas and discuss whether the observed granulomas represent a reactive phenomenon or true sarcoidosis. Click here for the corresponding questions to this CME article.

Publication types

Case Reports

MeSH terms

Connective Tissue Diseases* / complications
Granuloma / etiology
Humans
Sarcoidosis* / complications
Sarcoidosis* / diagnosis
Skin Diseases* / etiology