Screening for colorectal carcinoma in cancer family syndrome kindreds

Scand J Gastroenterol. 1987 May;22(4):449-53. doi: 10.3109/00365528708991489.


Screening for colorectal carcinoma (CRC) was organized for 236 asymptomatic family members in 22 Finnish cancer family syndrome (CFS) kindreds, and 58% (137) of the subjects accepted the invitation. Double-contrast colonography and sigmoidoscopy or colonoscopy were used. In 137 subjects aged 20-65 years, with 3 or more first-degree relatives with CRC, one screening visit showed a colonic neoplasm in 12 (9%) subjects. Two had carcinoma (Dukes A and B), and 10 subjects one or more adenomas. Two of the subjects not attending screening (2%) developed Dukes C colon carcinoma during the study period, and one of them died of cancer. Continued screening of 34 patients with a previously identified CFS showed metachronous colorectal tumours in 12 (35%) cases: 9 operable carcinomas and 9 adenomas within 3 years. The preliminary result of screening on the basis of CFS was encouraging. Effective and continuous screening, however, requires centralized organization. The continued follow-up of identified CFS cases effectively revealed metachronous colorectal tumours at a curable stage, but its benefit was burdened by a high rate of advanced malignancies other than CRC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma / epidemiology*
  • Adenoma / genetics
  • Adult
  • Aged
  • Carcinoma / epidemiology*
  • Carcinoma / genetics
  • Colorectal Neoplasms, Hereditary Nonpolyposis / epidemiology*
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
  • Female
  • Finland
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Risk