Factors impacting on patient setup analysis and error management during breast cancer radiotherapy

Crit Rev Oncol Hematol. 2022 Oct;178:103798. doi: 10.1016/j.critrevonc.2022.103798. Epub 2022 Aug 27.


Radiotherapy is required to deliver an accurate dose to the tumor while protecting surrounding normal tissues. Breast cancer radiotherapy involves a number of factors that can influence patient setup and error management, including the immobilization device used, the verification system and the patient's treatment position. The aim of this review is to compile and discuss the setup errors that occur due to the above-mentioned factors. In view of this, a systematic search of the scientific literature in the Medline/PubMed databases was performed over the 1990-2021 time period, with 93 articles found to be relevant for the study. To be accessible to all, this study not only aims to identify factors impacting on patient setup analysis, but also seeks to evaluate the role of each verification device, board immobilization and position in influencing these errors.

Keywords: Cone beam computed tomography; Immobilization; Organs at risk; Portal image; Positioning errors; Reproducibility.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Breast Neoplasms* / radiotherapy
  • Female
  • Humans
  • Patient Positioning
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Setup Errors
  • Radiotherapy, Image-Guided*