Evolving perspectives on rosetting in malaria

Trends Parasitol. 2022 Oct;38(10):882-889. doi: 10.1016/j.pt.2022.08.001. Epub 2022 Aug 26.


The ability of the intraerythrocytic Plasmodium spp. to form spontaneous rosettes with uninfected red blood cells (URBCs) has been observed in the medically important malaria parasites. Since the discovery of rosettes in the late 1980s, different formation mechanisms and pathobiological roles have been postulated for rosetting; most of which have focused on Plasmodium falciparum. Recent breakthroughs, including new data from Plasmodium vivax, have highlighted the multifaceted roles of rosetting in the immunopathobiology and the development of drug resistance in human malaria. Here, we provide new perspectives on the formation and the role of rosetting in malaria rheopathobiology.

Keywords: cytoadherence; malaria; pathobiological roles; rheopathobiology; rosette.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Adhesion
  • Erythrocytes / parasitology
  • Humans
  • Malaria*
  • Malaria, Falciparum* / parasitology
  • Plasmodium falciparum
  • Plasmodium vivax
  • Rosette Formation