The role of fascin-1 in the pathogenesis, diagnosis and management of respiratory related cancers

Naibin Zhang; Yankun Gao; Qiang Bian; Qianqian Wang; Ying Shi; Zhankui Zhao; Honglian Yu

doi:10.3389/fonc.2022.948110

The role of fascin-1 in the pathogenesis, diagnosis and management of respiratory related cancers

Front Oncol. 2022 Aug 11:12:948110. doi: 10.3389/fonc.2022.948110. eCollection 2022.

Authors

Naibin Zhang¹, Yankun Gao¹, Qiang Bian^{2

3}, Qianqian Wang¹, Ying Shi¹, Zhankui Zhao⁴, Honglian Yu^{1

2}

Affiliations

¹ Department of biochemistry, Jining Medical University, Jining, China.
² Collaborative Innovation Center, Jining Medical University, Jining, China.
³ Department of Pathophysiology, Weifang Medical University, Weifang, China.
⁴ The Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, China.

Abstract

Human cancer statistics report that respiratory related cancers such as lung, laryngeal, oral and nasopharyngeal cancers account for a large proportion of tumors, and tumor metastasis remains the major reason for patient death. The metastasis of tumor cells requires actin cytoskeleton remodeling, in which fascin-1 plays an important role. Fascin-1 can cross-link F-actin microfilaments into bundles and form finger-like cell protrusions. Some studies have shown that fascin-1 is overexpressed in human tumors and is associated with tumor growth, migration and invasion. The role of fascin-1 in respiratory related cancers is not very clear. The main purpose of this study was to provide an updated literature review on the role of fascin-1 in the pathogenesis, diagnosis and management of respiratory related cancers. These studies suggested that fascin-1 can serve as an emerging biomarker and potential therapeutic target, and has attracted widespread attention.

Keywords: biomarker; diagnosis; fascin-1; pathogenesis; respiratory related cancers; treatment.

Publication types

Review