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. 2022 Oct;19(10):e202200731.
doi: 10.1002/cbdv.202200731. Epub 2022 Sep 26.

New Diterpene and Indole Alkaloid Analogs from the Streptomyces malaysiensis SCSIO 41397

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New Diterpene and Indole Alkaloid Analogs from the Streptomyces malaysiensis SCSIO 41397

Yuhui Xie et al. Chem Biodivers. 2022 Oct.

Abstract

One new cyclooctatin-type diterpenoid, 15-hydroxycyclooctatin (1), and one new indole alkaloid, streptoprenylindole D (3), along with 9 known compounds, were isolated from the Streptomyces malaysiensis SCSIO 41397. Their structures were established on the basis of spectroscopic analysis, optical rotation, and by a comparison with data from the literature. All isolated compounds were evaluated for their antibacterial (MRSA), antitumor (22Rv1 and PC-3) and antiviral (HSV-1/2) activities. According to the analysis of biological gene clusters in the whole genome, we preliminarily locate the gene clusters related to the synthesis of 15-hydroxycyclooctatin (1).

Keywords: Marine Streptomyces; cyclooctatin; diterpenoid; indole alkaloid; streptoprenylindole.

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References

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