A simple model of the build-up of resistance to mixtures of anti-malarial drugs

Trans R Soc Trop Med Hyg. 1986;80(6):889-92. doi: 10.1016/0035-9203(86)90248-8.

Abstract

In an organism with a life-cycle modelled on that of Plasmodium two separate resistance genes are assumed, each protecting against one of two unrelated drugs. The model was used to compare the rates of build-up of resistance in a population where the two drugs are used either as a mixture or in sequence. The model suggests that the use of a mixture would be advantageous if: both resistances are initially rare; there is recombination between the genes; a large proportion of the parasite population is unexposed to the drugs.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / pharmacology*
  • Drug Combinations
  • Drug Resistance / genetics
  • Gene Frequency
  • Models, Genetic*
  • Plasmodium / drug effects*
  • Plasmodium / genetics
  • R Factors
  • Recombination, Genetic

Substances

  • Antimalarials
  • Drug Combinations