Posttranslational control of lipogenesis in the tumor microenvironment

J Hematol Oncol. 2022 Aug 29;15(1):120. doi: 10.1186/s13045-022-01340-1.


Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs in response to increased nutritional, translation and proliferative demands. Altered lipid metabolism is a marker of tumor progression that is frequently observed in aggressive tumors with poor prognosis. Underlying these abnormal metabolic behaviors are posttranslational modifications (PTMs) of lipid metabolism-related enzymes and other factors that can impact their activity and/or subcellular localization. This review focuses on the roles of these PTMs and specifically on how they permit the re-wiring of cancer lipid metabolism, particularly within the context of the tumor microenvironment.

Keywords: Cancer; Lipid metabolism reprogramming; Posttranslational modification; Tumor microenvironment.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Lipid Metabolism
  • Lipogenesis
  • Neoplasms* / pathology
  • Protein Processing, Post-Translational
  • Tumor Microenvironment*