Posttreatment Exposure Rates for 90Y-Microsphere Patients: A Comparison of Products

J Nucl Med Technol. 2023 Mar;51(1):60-62. doi: 10.2967/jnmt.122.264335. Epub 2022 Aug 30.


There has been a significant increase in the use of 90Y-microspheres in treating liver malignancies. This increase could be seen over the last 30 y, and Food and Drug Administration approval of 2 products-Sirtex SIR-Spheres and Boston Scientific TheraSphere-has helped in the proliferation of these treatments. As the increase in use of both products rose at our institution, there was a need to determine whether there should be special considerations for patients who receive one product compared with patients who receive the other product. This determination was made by measuring exposure rates for several regions of the patient before and after implantation. An independent-samples t test analysis (ɑ = 0.05) was performed for 50 patients (25 TheraSphere and 25 SIR-Spheres) to determine whether the products behaved similarly to the extent that exposure to others was minimized and that as-low-as-reasonably-achievable principles were kept. The results showed that the products exhibited no significant differences in exposure rates, suggesting that no special considerations are needed for the procedure for one product compared with the other.

Keywords: 90Y; 90Y-microspheres; SIR-Spheres; TheraSphere; yttrium-90.

MeSH terms

  • Humans
  • Liver Neoplasms*
  • Microspheres
  • Radiopharmaceuticals / therapeutic use
  • Yttrium Radioisotopes / therapeutic use


  • Radiopharmaceuticals
  • Yttrium Radioisotopes