Collagen peptide supplementation for pain and function: is it effective?

Curr Opin Clin Nutr Metab Care. 2022 Nov 1;25(6):401-406. doi: 10.1097/MCO.0000000000000870. Epub 2022 Aug 31.


Purpose of review: Connective tissue injuries are prevalent in active and aging populations, leading to chronic pain and decreased function. Turnover of this tissue is not well understood, especially as it relates to aging and injury. Supplementation of collagen peptides has been shown to improve connective tissue recovery and pain through increased collagen production.

Recent findings: Collagen peptide supplementation improves pain and function, and upregulates metabolic pathways associated with muscle and tendon growth. Literature from the past 12-18 months supports that these pathways are also involved with increased synthesis and degradation of collagen and other elements of the extracellular matrix. Improvements in body composition and strength have been noted with collagen peptide supplementation when paired with resistance training. Collagen peptide supplements are hydrolyzed into small peptides, termed bioactive peptides, and individual amino acids. These bioactive peptides are associated with the benefits observed with collagen peptide supplementation and may play a critical role in the collagen turnover.

Summary: Collagen peptide supplementation has been shown to promote recovery, decrease pain, and improve strength and body composition when paired with resistance training. These benefits may be attributed to bioactive peptides in collagen peptide supplements. Additional research is warranted to examine the specific effects of these bioactive peptides.

Publication types

  • Review

MeSH terms

  • Amino Acids
  • Collagen* / chemistry
  • Dietary Supplements
  • Humans
  • Pain
  • Peptides* / pharmacology
  • Peptides* / therapeutic use


  • Amino Acids
  • Peptides
  • Collagen