A rare case of a giant cell tumour caused by vitamin D deficiency

Folia Med (Plovdiv). 2022 Aug 31;64(4):676-681. doi: 10.3897/folmed.64.e63623.


Reparative giant cell granulomas are benign masses of multi-etiological nature, which account for 1%-7% of all benign lesions of the jaws. The objective of this case report is to present the relationship between isolated vitamin D deficiency and the development of reparative giant cell granuloma.Herein, we present the case of a 70-year-old female patient with a painless mass of increased mobility in the mandibular region, and pain in the involved teeth. After histological confirmation and laboratory screening, а reparative giant cell granuloma caused by serious deficiency of vitamin D3 - (25-OH)D was diagnosed. The treatment protocol included surgical removal of the lesion and vitamin D replacement therapy.In rare cases, this type of lesion can be a primary manifestation of vitamin D deficiency; therefore, it is extremely important to be aware of this pathology.

Keywords: mandible; reparative giant cell granuloma; vitamin D deficiency.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Cholecalciferol / therapeutic use
  • Female
  • Giant Cell Tumors*
  • Granuloma, Giant Cell* / diagnosis
  • Granuloma, Giant Cell* / etiology
  • Granuloma, Giant Cell* / surgery
  • Humans
  • Vitamin D
  • Vitamin D Deficiency* / complications


  • Vitamin D
  • Cholecalciferol